Alfons A den Broeder Selected Research

Drug Tapering

10/2022	Treat-to-target dose reduction and withdrawal strategy of TNF inhibitors in psoriatic arthritis and axial spondyloarthritis: a randomised controlled non-inferiority trial.
8/2022	Serum drug levels and anti-drug antibodies in the context of dose tapering by interval prolongation of adalimumab, etanercept and ustekinumab in psoriasis patients: results of the CONDOR trial.
12/2020	Health Economic Consequences of a Tightly Controlled Dose Reduction Strategy for Adalimumab, Etanercept and Ustekinumab Compared with Standard Psoriasis Care: A Cost-utility Analysis of the CONDOR Study.
1/2020	Dose reduction and withdrawal strategy for TNF-inhibitors in psoriatic arthritis and axial spondyloarthritis: design of a pragmatic open-label, randomised, non-inferiority trial.
1/2020	Comparison of Tightly Controlled Dose Reduction of Biologics With Usual Care for Patients With Psoriasis: A Randomized Clinical Trial.
11/2018	The patient perspective on biologic DMARD dose reduction in rheumatoid arthritis: a mixed methods study.
10/2017	Long-term outcomes after disease activity-guided dose reduction of TNF inhibition in rheumatoid arthritis: 3-year data of the DRESS study - a randomised controlled pragmatic non-inferiority strategy trial.
6/2017	bDMARD Dose Reduction in Rheumatoid Arthritis: A Narrative Review with Systematic Literature Search.
2/2017	Little Evidence for Usefulness of Biomarkers for Predicting Successful Dose Reduction or Discontinuation of a Biologic Agent in Rheumatoid Arthritis: A Systematic Review.
1/2017	Tight controlled dose reduction of biologics in psoriasis patients with low disease activity: a randomized pragmatic non-inferiority trial.

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Alfons A den Broeder Research Topics

Disease

57	Rheumatoid Arthritis 10/2022 - 06/2002
8	Necrosis 01/2020 - 06/2013
7	Pain (Aches) 01/2021 - 07/2011
6	Infections 06/2022 - 01/2011
5	Psoriatic Arthritis 10/2022 - 01/2018
5	Rheumatic Diseases (Rheumatism) 01/2021 - 01/2018
4	Axial Spondyloarthritis 10/2022 - 01/2020
4	Psoriasis (Pustulosis Palmaris et Plantaris) 08/2022 - 01/2017
4	Knee Osteoarthritis 01/2020 - 07/2011
3	Ankylosing Spondylitis 01/2022 - 01/2018
3	Inflammation (Inflammations) 08/2015 - 08/2013
2	Polymyalgia Rheumatica (Rhizomelic Pseudopolyarthritis) 04/2022 - 01/2021
2	COVID-19 01/2022 - 01/2022
2	Disease Progression 10/2019 - 11/2015
2	Fibromyalgia (Fibrositis) 01/2016 - 08/2015
2	Osteoarthritis 11/2015 - 07/2011
1	Neutropenia 06/2022
1	Gout 05/2022
1	Diabetes Mellitus 05/2022
1	Cardiovascular Diseases (Cardiovascular Disease) 09/2017
1	Hyperglycemia 07/2017
1	Hypoglycemia (Reactive Hypoglycemia) 07/2017
1	Critical Illness (Critically Ill) 07/2017
1	Muscular Diseases (Myopathy) 01/2016
1	Thyroid Diseases (Thyroid Disease) 01/2016
1	Osteoporosis 08/2015
1	Lung Diseases (Lung Disease) 08/2015
1	Acute-Phase Reaction 03/2015
1	Tuberculosis (Tuberculoses) 01/2015
1	Q Fever (Fever, Q) 06/2014

Drug/Important Bio-Agent (IBA)

14	Adalimumab (Humira)FDA Link 08/2022 - 06/2013
14	Biological ProductsIBA 06/2022 - 01/2015
12	Pharmaceutical PreparationsIBA 10/2022 - 01/2011
12	Etanercept (Enbrel)FDA Link 08/2022 - 06/2013
10	Antirheumatic Agents (DMARD)IBA 06/2022 - 01/2014
10	Methotrexate (Mexate)FDA LinkGeneric 04/2022 - 10/2009
8	Rituximab (Mabthera)FDA Link 10/2022 - 11/2011
8	Tumor Necrosis Factor InhibitorsIBA 10/2022 - 06/2013
7	Infliximab (Remicade)FDA Link 01/2020 - 01/2011
7	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2014 - 06/2002
6	AntibodiesIBA 10/2022 - 01/2011
4	Biosimilar PharmaceuticalsIBA 01/2020 - 08/2015
3	Ustekinumab (CNTO 1275)FDA Link 08/2022 - 01/2020
3	Sulfasalazine (Azulfidine)FDA LinkGeneric 01/2020 - 04/2007
3	CytokinesIBA 05/2019 - 01/2018
2	Leflunomide (Arava)FDA LinkGeneric 02/2020 - 01/2020
2	Abatacept (Orencia)FDA Link 01/2020 - 01/2018
2	tocilizumab (atlizumab)FDA Link 01/2020 - 01/2018
2	golimumab FDA Link 01/2020 - 01/2018
2	GlucocorticoidsIBA 01/2020 - 11/2014
2	Biomarkers (Surrogate Marker)IBA 02/2017 - 01/2017
1	Adrenal Cortex Hormones (Corticosteroids)IBA 06/2022
1	Immunoglobulins (Immunoglobulin)IBA 06/2022
1	Metformin (Glucophage)FDA LinkGeneric 05/2022
1	Uric Acid (Urate)IBA 05/2022
1	Allopurinol (Remid)FDA LinkGeneric 05/2022
1	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 01/2022
1	Dichlorodiphenyldichloroethane (DDD)IBA 01/2022
1	COVID-19 VaccinesIBA 01/2022
1	VaccinesIBA 01/2022
1	ORALIT (ORS)IBA 01/2022
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 01/2021
1	baricitinibIBA 01/2020
1	Janus Kinase InhibitorsIBA 01/2020
1	Janus KinasesIBA 01/2020
1	tofacitinibIBA 01/2020
1	upadacitinibIBA 01/2020
1	sarilumabIBA 01/2020
1	Certolizumab Pegol FDA Link 01/2020
1	GLPG0634IBA 01/2020
1	Hormones (Hormone)IBA 10/2019
1	SteroidsIBA 10/2019
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2019
1	Analgesics (Analgesic Drugs)IBA 01/2019
1	salicylhydroxamic acid (SHAM)IBA 01/2019
1	Leukocyte L1 Antigen Complex (Calgranulin)IBA 01/2018
1	CT-P13IBA 01/2018
1	zaleplon (Sonata)FDA LinkGeneric 01/2018
1	C-Reactive ProteinIBA 01/2018
1	Anti-Idiotypic AntibodiesIBA 09/2017
1	Peptides (Polypeptides)IBA 09/2017
1	Rheumatoid FactorIBA 09/2017
1	Blood Glucose (Blood Sugar)IBA 07/2017
1	Glucose (Dextrose)FDA LinkGeneric 07/2017
1	Insulin (Novolin)FDA Link 07/2017
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2016
1	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 01/2016
1	Folic Acid (Vitamin M)FDA LinkGeneric 09/2015
1	ametantrone (HAQ)IBA 08/2015
1	Anti-Citrullinated Protein AntibodiesIBA 03/2015
1	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 11/2014

Therapy/Procedure

14	Drug Tapering 10/2022 - 10/2013
10	Therapeutics 02/2020 - 06/2002
2	Exercise Therapy (Therapy, Exercise) 01/2022 - 01/2019
2	Radiotherapy 01/2020 - 01/2019
2	Aftercare (After-Treatment) 01/2020 - 01/2020
1	Retreatment 10/2022
1	Biological Therapy 01/2017
1	Knee Replacement Arthroplasty (Total Knee Replacement) 11/2015
1	Cell- and Tissue-Based Therapy (Cell Therapy) 06/2014